Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens.
It is identical with CR-3, the receptor for the iC3b fragment of the third complement component.
It probably recognizes the R-G-D peptide in C3b.
Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1.
It recognizes P1 and P2 peptides of fibrinogen gamma chain.
In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils.
May regulate phagocytosis-induced apoptosis in extravasated neutrophils.
May play a role in mast cell development.
Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development.
特徴
Human ITGAM&ITGB2 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAM and ITGB2, has a calculated MW of 127.2 kDa (ITGAM) and 80.2 kDa (ITGB2).
Subunit ITGAM is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB2 contains no tag but a basic tail at the C-terminus.
The non-reducing (NR) protein migrates as 150-180 kDa (ITGAM) and 85-95 kDa (ITGB2) respectively due to glycosylation.
仕様
容量：100ug
Source：Human ITGAM&ITGB2 Heterodimer Protein, His Tag&Tag Free (IT2-H52W4) is expressed from human 293 cells (HEK293). It contains AA Phe 17 - Asn 1105 (ITGAM) & Gln 23 - Asn 700 (ITGB2) (Accession # P11215-2 (ITGAM) & P05107-1 (ITGB2)).
