Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4.
Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion.
Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration.
特徴
Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA3 and ITGB1, has a calculated MW of 133.3 kDa (ITGA3) and 83.7 kDa (ITGB1).
Subunit ITGA3 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The non-reducing (NR) protein migrates as 125-150 kDa (ITGA3) and 100-110 kDa (ITGB1) respectively due to glycosylation.
仕様
容量：100ug
Source：Human ITGA3&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wc) is expressed from human 293 cells (HEK293). It contains AA Phe 33 - Glu 991 (ITGA3) & Gln 21 - Asp 728 (ITGB1) (Accession # P26006-2 (ITGA3) & P05556-1 (ITGB1)).
