Integrin alpha-1/beta-1 is a receptor for laminin and collagen.
The Integrin alpha-1/beta-1 and Integrin alpha-2/beta-1 integrins provide critical support for vascular endothelial growth factor signaling, endothelial cell migration, and tumor angiogenesis.
It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.
特徴
Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA1 and ITGB1, has a calculated MW of 130.0 kDa (ITGA1) and 83.7 kDa (ITGB1).
Subunit ITGA1 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The protein migrates as 170-200 kDa (ITGA1) and 100-130 kDa (ITGB1) under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human ITGA1&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52Wb) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1) (Accession # P56199-1 (ITGA1) & P05556-1 (ITGB1)).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His | Native
Exp Region：Phe 29 - Pro 1141 (ITGA1) & Gln 21 - Asp 728 (ITGB1)
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P56199-1 (ITGA1) & P05556-1 (ITGB1)
Protein ID：NP_852478.1 (ITGA1) & NP_002202.2 (ITGB1)
