Integrin alpha 6 beta 1, also called platelet glycoprotein GPIc-IIa, is a receptor for laminin on platelets.
The ITGA6 protein product is the integrin alpha chain alpha 6.
Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain.
A given chain may combine with multiple partners resulting in different integrins.
For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6.
Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
ITGA6 has been shown to interact with TSPAN4 and GIPC1.
特徴
Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA6 and ITGB1, has a calculated MW of 116.8 kDa (ITGA6) and 83.7 kDa (ITGB1).
Subunit ITGA6 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The non-reducing (NR) protein migrates as 140-150 kDa (ITGA6) and 100-118 kDa (ITGB1) respectively due to glycosylation.
仕様
容量：1mg
Source：Human ITGA6&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W7) is expressed from human 293 cells (HEK293). It contains AA Phe 24 - Gly 1012 (ITGA6) & Gln 21 - Asp 728 (ITGB1) (Accession # P23229-2 (ITGA6) & P05556-1 (ITGB1)).
