Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit.
It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin.
It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.
It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.
Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8.
DGEA inhibited rotavirus binding to alpha2beta1 and infectivity.
In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.
特徴
Human ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA2 and ITGB1, has a calculated MW of 127.6 kDa (ITGA2) and 83.7 kDa (ITGB1).
Subunit ITGA2 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The reducing (R) protein migrates as 150-160 kDa (ITGA2) and 105-135 kDa (ITGB1) respectively due to glycosylation.
仕様
容量：1mg
Source：Human ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W6) is expressed from human 293 cells (HEK293). It contains AA Tyr 30 - Thr 1132 (ITGA2) & Gln 21 - Asp 728 (ITGB1) (Accession # P17301-1 (ITGA2) & P05556-1 (ITGB1)).
