Integrin alpha 9 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 (CD29) subunit.
It is the non-covalent heterodimer of 150 kDa alpha 9 and 130 kDa beta 1 type I transmembrane glycoprotein subunits.
The integrin alpha 9 beta 1 mediates cell adhesion to tenascin-C and VCAM-1 by binding to sequences distinct from the common integrin-recognition sequence, arginine-glycine-aspartic acid (RGD).
A thrombin-cleaved NH(2)-terminal fragment of osteopontin containing the RGD sequence has recently been shown to also be a ligand for integrin alpha 9 beta 1.
特徴
Human ITGA9&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA9 and ITGB1, has a calculated MW of 111.1 kDa (ITGA9) and 82.7 kDa (ITGB1).
Subunit ITGA9 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus.
The reducing (NR) protein migrates as 210-240 kDa respectively due to glycosylation.
仕様
容量：100ug
Source：Human ITGA9&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-H52W4) is expressed from human 293 cells (HEK293). It contains AA Tyr 30 - Trp 981 (ITGA9) & Gln 21 - Asp 728 (ITGB1) (Accession # Q13797-1 (ITGA9) & P05556-1 (ITGB1)).
