Interleukin 23 receptor (IL-23R) is a type I cytokine receptor, and IL-23R pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling.
Also, IL-23R associates constitutively with Janus kinase 2 (JAK2), and binds to transcription activator STAT3 in a ligand-dependent manner.
Furthermore, IL-23R mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade.
As for IL-23, it may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 64.5 kDa.
The protein migrates as 90-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human IL-23 R, Fc Tag (ILR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gly 24 - Gly 355
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q5VWK5-1
Protein ID：NP_653302.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
