P-selectin glycoprotein ligand 1 (PSGL-1) is also known as Selectin P ligand (SELPLG), CD antigen CD162.
PSGL-1 is disulfide-linked homodimer which is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets.
PSGL-1 / SELPLG interacts with P-, E- and L-selectins, through their lectin/EGF domains, is required for promoting recruitment and rolling of leukocytes.
These interactions require sialyl Lewis X glycan modification but there is a differing dependence for tyrosine sulfations.
Dimerization appears not to be required for P-selectin/SELP binding.
PSGL-1 can interact with SNX20, MSN and SYK.
PSGL-1 / SELPLG mediate the activation of SYK by SELPLG.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 32.4 kDa.
The protein migrates as 55-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human PSGL-1, His,Avitag (PS1-H82E4) is expressed from human 293 cells (HEK293). It contains AA Gln 42 - Cys 320 (Accession # Q14242-1).
