83-3849-57 Human IL-18BP Protein, Fc Tag （MALS verified） 1mg ILP-H5253-1mg
特徴
- 背景
- Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor.
- IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain.
- IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane.
- IL18BP is strongly expressed in heart, lung, placenta and spleen.
- Isoform A of IL18BP binds to IL-18 and inhibits its activity.
- IL18BP also functions as an inhibitor of the early TH1 cytokine response.
- IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
- 特徴
- This protein carries a human IgG1 Fc tag at the C-terminus.
- The protein has a calculated MW of 44.3 kDa.
- The protein migrates as 56-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：1mg
- Source：Human IL-18BP, Fc Tag (ILP-H5253) is expressed from human 293 cells (HEK293). It contains AA Thr 31 - Gly 194 (Accession # NP_001138529).
- Species Reactivity：Human
- Host：HEK293
- Tag：C-Fc
- Exp Region：Thr 31 - Gly 194
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：O95998
- Protein ID：NP_001138529
- Endotoxin：1.0 EU per μg
- Purity：95%
- Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
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