Interleukin-18-binding protein (IL18BP) is also known as Tadekinig-alfa, IL18BPa, which functions as an IL18 inhibitor.
IL18BP is a secreted protein which contains one Ig-like C2-type (immunoglobulin-like) domain.
IL18BP does not have a transmembrane domain and hence is not anchored to the cell membrane.
IL18BP is strongly expressed in heart, lung, placenta and spleen.
Isoform A of IL18BP binds to IL-18 and inhibits its activity.
IL18BP also functions as an inhibitor of the early TH1 cytokine response.
IL18BP suppresses the production of IFN-gamma resulting in reduced T-helper type 1 immune responses.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 18.5 kDa.
The protein migrates as 35-45 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Human IL-18BP, His Tag (ILP-H5222) is expressed from human 293 cells (HEK293). It contains AA Thr 31 - Gly 194 (Accession # NP_001138529).
