PTK7, highly expressed in lung, liver, pancreas, kidney, placenta and melanocytes.
Weakly expressed in thyroid gland, ovary, brain, heart and skeletal muscle.
Also expressed in erythroleukemia cells.
Inactive tyrosine kinase involved in Wnt signaling pathway.
Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway.
Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis.
Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
特徴
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 78.2 kDa.
The protein migrates as 105-115 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human PTK7, His,Avitag (PT7-H82E5) is expressed from human 293 cells (HEK293). It contains AA Ala 31 - Thr 704 (Accession # Q13308-1).
