Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.
IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines.
IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
特徴
Human IL-23A & Mouse IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23 alpha and IL-12 beta, has a calculated MW of 19.5 kDa (IL-23 alpha) and 35.8 kDa (IL-12 beta).
Subunit IL-23 alpha is fused with a polyhistidine tag at the N-terminus and subunit IL-12 beta contains no tag.
The protein migrates as 20 kDa (IL23A) & 45 kDa (IL12B) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Human IL-23 alpha&Mouse IL-12 beta Heterodimer Protein, His Tag&Tag Free (ILB-HM52W6) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P43432-1 (IL12B)).
Species Reactivity：Human & Mouse
Host：HEK293
Tag：N-6×His | Native
Exp Region：Arg 20 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B)
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q9NPF7-1 (IL23A) & P43432-1 (IL12B)
Protein ID：NP_057668.1 (IL23A) & NP_032378.1 (IL12B)
