Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.
IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines.
IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
特徴
Biotinylated Human IL-23A&IL-12B Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of IL23A and IL12B, has a calculated MW of 21.9 kDa (IL23A) & 34.7 kDa (IL12B).
Subunit IL23A is fused with an Avi tag (Avitag), followed by a polyhistidine tag at the N-terminus and subunit IL12B contains no tag.
The predicted N-terminus is His (IL23A) & Ile 23 (IL12B).
The reducing (R) protein migrates as 26 kDa (IL23A) & 40-45 kDa (IL12B) respectively due to glycosylation.
仕様
容量：25ug
Source：Biotinylated Human IL-23 alpha&IL-12 beta Heterodimer Protein, His,Avitag&Tag Free (ILB-H82W6) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B) (Accession # Q9NPF7-1 (IL23A) & P29460-1 (IL12B)).
Species Reactivity：Human
Host：HEK293
Tag：N-10×His & N-Avi | Native
Exp Region：Arg 20 - Pro 189 (IL23A) & Ile 23 - Ser 328 (IL12B)
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q9NPF7-1 (IL23A) & P29460-1 (IL12B)
Protein ID：NP_057668.1 (IL23A) & NP_002178.2 (IL12B)
