83-3848-87 Mouse CLEC12A / MICL / CLL-1 Protein, His Tag 100ug CLA-M5244-100ug
特徴
- 背景
- CLEC12A (C-type lectin domain family 12 member A) is also known as CLL1, DCAL2, MICL.
- Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death.
- Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
- Evidence of distinct disease propagating stem cells in myelodysplastic syndrome (MDS) has emerged in recent years.
- The role of CLEC12A in MDS, however, remains to be elucidated.
- Furthermore, CLEC12A has been proposed as a promising marker of leukaemic stem cells in AML.
- 特徴
- This protein carries a polyhistidine tag at the N-terminus.
- The protein has a calculated MW of 25.7 kDa.
- The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
- 容量：100ug
- Source：Mouse CLEC12A, His Tag (CLA-M5244) is expressed from human 293 cells (HEK293). It contains AA Tyr 65 - Arg 267 (Accession # Q504P2-1).
- Species Reactivity：Mouse
- Host：HEK293
- Tag：N-10×His
- Exp Region：Tyr 65 - Arg 267
- Format：Powder
- Conjugate：Unconjugated
- Swiss-Prot：Q504P2-1
- Endotoxin：1.0 EU per μg
- Purity：90%
- Buffer：PBS, pH7.4
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