83-3848-75　Human IL-12 R beta 1 / CD212 Protein, Fc Tag 1mg　ILB-H5255-1mg

特徴

• 背景
• The human IL-12 R subunit is a member of the cytokine receptor superfamily and the functional high-affinity IL-12R is composed of at least two beta-type cytokine receptor subunits, each independently exhibiting a low affinity for IL-12.
• IL-12 R beta 1 (Interleukin-12 receptor subunit beta-1) is also known as IL-12RB1, CD212.
• Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
• Associated with IL12RB2 it forms a functional, high affinity receptor for IL12.
• Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 83.5 kDa.
• The protein migrates as 95-120 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.