Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity.
IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues.
IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines.
IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
特徴
This protein carries polyhistidine tag at the N-terminus.
The protein has a calculated MW of 20.3 kDa (IL23A) & 35.8 kDa (IL12B).
The protein migrates as 20-23 kDa (IL23A) & 40-42 kDa and 43-46 kDa (IL12B) when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：50ug
Source：Cynomolgus IL-23A&Mouse IL-12B Heterodimer Protein, His Tag&Tag Free (ILB-CM52W8) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B) (Accession # A0A2K5TLV4-1 (IL23A) & P43432-1 (IL12B)).
Species Reactivity：Cynomolgus & Mouse
Host：HEK293
Tag：N-10×His | Native
Exp Region：Val 22 - Pro 189 (IL23A) & Met 23 - Ser 335 (IL12B)
