IL15R is a heterotrimer of IL15RA, IL2RB and IL2RG.
IL-15RA, also known as CD215, IL-15 R alpha, is a widely expressed 60 kDa transmembrane glycoprotein.
High-affinity receptor for interleukin-15.
Can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells.
Expression of different isoforms may alter or interfere with signal transduction.
An interleukin (IL)-15 superagonist/IL-15 receptor α fusion complex (IL-15SA/IL-15RA; ALT-803) activates the IL-15 receptor on CD8 T cells and NK cells, and has shown significant anti-tumor.
Signal transduction involves SYK.
Higher levels of soluble sIL-15RA form in comparison with membrane-bound forms is present in all brain structures.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
The protein has a calculated MW of 46.6 kDa.
The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：Biotinylated Human IL-15 R alpha, Fc,Avitag (ILA-H82F4) is expressed from human 293 cells (HEK293). It contains AA Ile 31 - Thr 205 (Accession # Q13261-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc & C-Avi
Exp Region：Ile 31 - Thr 205
Format：Powder
Conjugate：Biotin-labeled
Swiss-Prot：Q13261-1
Protein ID：NP_002180.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
