The fourth member of the leucine-rich repeat-containing GPCR family (LGR4, frequently referred to as GPR48) together with its family members LGR5 and -6, bind to R-spondins (RSPOs)-1–4 and result in Wnt signaling potentiation.
In addition, LGR4 (as well as LGR5 and -6) is implicated in multiple cancers and promotes invasion and metastasis in colorectal, prostate, and cervical cancer cell lines.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 58.8 kDa.
The protein migrates as 70-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human LGR4, His Tag (LG4-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 25 -Thr 544 (Accession # Q9BXB1-1).
