Hepatocyte growth factor (HGF) is a paracrine cellular growth, motility and morphogenic factor.
Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization.
Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin.
Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.
In addition, HGF has been implicated in a variety of cancers, including of the lungs, pancreas, thyroid, colon, and breast.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 106.1 kDa.
The protein migrates as 105-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human HGF, Fc Tag (HGF-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 32 - Ser 728 (Accession # P14210-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gln 32 - Ser 728
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P14210-1
Protein ID：NP_000592.3
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5
