83-3847-83　Biotinylated Mouse IL-15 Protein, Fc,Avitag 200ug　IL5-M82F3-200ug

特徴

• 背景
• Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2.
• Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132).
• IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es).
• This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
• Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation.
• Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15.
• This cytokine is also implicated in NK cell development.
• In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L).
• IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models.
• A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus, followed by an Avi tag (Avitag).
• The protein has a calculated MW of 41.5 kDa.
• The protein migrates as 50-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.