Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2.
Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132).
IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es).
This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells.
Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation.
Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15.
This cytokine is also implicated in NK cell development.
In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L).
IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models.
A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 14.8 kDa.
The protein migrates as 17-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IL-15, His Tag (IL5-H52H8) is expressed from human 293 cells (HEK293). It contains AA Asn 49 - Ser 162 (Accession # P40933-1).
