Interleukin-4, is a cytokine that induces differentiation of naive helper T cells (Th0 cells to Th2 cells).
In the presence of IL-4 and IL-13, cytokines that are produced in a Th-2 type response, particularly during allergy and parasitic infections, macrophages become differentially activated, And this cytokine is a ligand for interleukin 4 receptor.
The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13.
STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine.
Recently, researcher found that the cytokine IL-4 plays a key role in development of innate CD8+ T cells in the thymus of several gene-deficient mouse strains, including Itk, KLF2, CBP and Id3, without previous exposure to antigen.
特徴
This protein carries an Avi tag (Avitag) at the C-terminus, followed by a polyhistidine tag.
The protein has a calculated MW of 17.6 kDa.
As a result of glycosylation, the protein migrates as 22 kDa under reducing (R) condition, and 21 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：200ug
Source：Biotinylated Human IL-4, Avitag,His Tag (IL4-H82E0) is expressed from human 293 cells (HEK293). It contains AA His 25 - Ser 153 (Accession # AAH67514).
