83-3847-50　Biotinylated Human IL-2 Protein, Fc,Avitag 25ug　IL2-H82F3-25ug

特徴

• 背景
• Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self.
• IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity.
• Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively.
• Human and mouse IL-2 exhibit crossspecies activity.
• The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes.
• IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs).
• After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against "self antigens", which could result in "autoimmunity".
• T-Regs do so by preventing the responding cells from producing IL-2.
• Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.
• 特徴
• This protein carries a human IgG1 Fc tag at the N-terminus and an Avi tag (Avitag) at the C-terminus.
• The protein has a calculated MW of 43.7 kDa.
• The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.