Interleukin-1 receptor type 2 (IL1R2) is also known as CD121 antigen-like family member B (CDw121b), IL-1 type II receptor, Interleukin-1 receptor type II, belongs to the interleukin-1 receptor family.
Two distinct types of IL1 receptors which are able to bind IL1 specifically have been identified, designated as IL1RI (IL1RA) and IL1RII (IL1RB).
IL1R2 is non-signaling receptor for IL1A, IL1B and IL1RN, reduces IL1B activities.
Serves as a decoy receptor by competetive binding to IL1B and preventing its binding to IL1R1.
IL1R2 modulates cellular response through non-signaling association with IL1RAP after binding to IL1B.
IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN.
The secreted IL1R2 recruits secreted IL1RAP with high affinity; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 63.9 kDa.
The protein migrates as 70-85 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IL-1 RII, Fc Tag (IL2-H4256) is expressed from human 293 cells (HEK293). It contains AA Phe 14 - Glu 343 (Accession # NP_004624.1).
