Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40).
IL-12 is involved in the differentiation of naive T cells into Th1 cells.
It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells.
It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ.
IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.
IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
特徴
Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 36.6 kDa (IL-12B) and 23.8 kDa (IL-12A).
Subunit IL-12B is fused with polyhistidine tag at the C-terminus and subunit IL-12A is fused with flag tag at the C-terminus.
The reducing (R) heterodimer protein migrates as 45 kDa (IL12B) and 38-43 kDa (IL12A) respectively due to glyosylation.
仕様
容量：20ug
Source：Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag (IL2-H4210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A) (Accession # P29460-1 (IL12B) & P29459-1 (IL12A)).
Species Reactivity：Human
Host：HEK293
Tag：C-10×His | C-Flag
Exp Region：Ile 23 - Ser 328 (IL-12B) & Arg 23 - Ser 219 (IL-12A)
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P29460-1 (IL12B) & P29459-1 (IL12A)
Protein ID：NP_002178.2 (IL12B) & NP_000873.2 (IL12A)
