IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens.
Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.
May function in skin immunity.
IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.
IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.
These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.7 kDa.
The protein migrates as 23-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human IL-31, His Tag (IL1-H5247) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Thr 164 (Accession # Q6EBC2-1).
