83-3846-95　Cynomolgus IL-31 Protein, His Tag 1mg　IL1-C5245-1mg

特徴

• 背景
• IL-31 is an inflammatory cytokine that helps trigger cell-mediated immunity against pathogens.
• Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
• It has also been identified as a major player in a number of chronic inflammatory diseases, including atopic dermatitis.
• May function in skin immunity.
• IL-31 is produced by a variety of cells, namely type 2 helper (TH2) T-cells.
• IL-31 sends signals through a receptor complex made of IL-31RA and oncostatin M receptor β (OSMRβ) expressed in immune and epithelial cells.
• These signals activate three pathways: ERK1/2 MAP kinase, PI3K/AKT, and JAK1/2 signaling pathways.
• 特徴
• This protein carries a polyhistidine tag at the N-terminus.
• The protein has a calculated MW of 17.3 kDa.
• The protein migrates as 20-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.