Interleukin-10 (IL-10) is also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine.
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes.
Mature human IL-10 shares 72% - 86% amino acid sequence identity with bovine, canine, equine, feline, mouse, ovine, porcine, and rat IL-10.
Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells.
IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and regulatory T-cells.
It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells.
However, it is also stimulatory towards certain T cells and mast cells and stimulates B cell maturation and antibody production.
Knockout studies suggested the function of Interleukin-10 / IL-10 as an essential immunoregulator in the intestinal tract.
Patients with Crohn's disease react favorably towards treatment with bacteria producing recombinant interleukin-10, showing the importance of interleukin-10 for counteracting excessive immunity in the human body.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 19.5 kDa.
The protein migrates as 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：20ug
Source：Human IL-10, His Tag (IL0-H4248) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Asn 178 (Accession # NP_000563.1).
