Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells.
In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment.
The Fc segment bears a highly conserved N-glycosylation site.
There are two members of IgG2: IgG2a and IgG2b.
It was found that IgG2a was superior to IgG1 in activating complement.
The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis.
特徴
This protein carries no "tag".
The protein has a calculated MW of 26.4 kDa.
As a result of glycosylation, the protein migrates as 30-35 kDa under reducing (R) condition, and 55-60 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：1mg
Source：Mouse IgG2a Fc, Tag Free (IGA-M5207) is expressed from human 293 cells (HEK293). It contains AA Glu 98 - Lys 330 (Accession # CAC20702).
Species Reactivity：Mouse
Host：HEK293
Tag：Native
Exp Region：Glu 98 - Lys 330
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P01863.1
Protein ID：CAC20702
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
