Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain.
IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms.
Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro.
Its inhibitory action has been shown in vivo in prostate and colon.
IGFBP-4 is secreted by all colon cancer cells.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 27.9 kDa.
The protein migrates as 33-37 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IGFBP-4, His Tag (IG4-H52E4) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Glu 258 (Accession # P22692-1).
