Immunoglobulin G2 (IgG2) is a member of many immunoglobulin G developed and secreted by effective B cells.
In wake of cutting by pepsin, IgG is divided into two F(ab)s with one antigen binding site and a high conserved Fc segment.
The Fc segment bears a highly conserved N-glycosylation site.
There are two members of IgG2: IgG2a and IgG2b.
It was found that IgG2a was superior to IgG1 in activating complement.
The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis.
Ig gamma-2 chain Fc region contains two constant regions of IgG2 H chain (CH2, CH3).
特徴
This protein carries no "tag".
The protein has a calculated MW of 25.7 kDa.
The protein migrates as 30-33 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human IgG2 Fc, Tag Free (IG2-H5206) is expressed from human 293 cells (HEK293). It contains AA Glu 99 - Lys 326 (Accession # P01859-1).
