High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.
HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity.
The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release.
This positions HMGB1 at the intersection of sterile and infectious inflammatory responses.
HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 26.8 kDa.
The protein migrates as 33 kDa and 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Mouse HMGB1, His Tag (HM1-M52H6) is expressed from human 293 cells (HEK293). It contains AA Met 1 - Glu 215 (Accession # P63158-1).
