High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3.
HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity.
The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release.
This positions HMGB1 at the intersection of sterile and infectious inflammatory responses.
HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
特徴
This protein carries a mouse IgG2a Fc tag at the N-terminus.
The protein has a calculated MW of 51.6 kDa.
The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human HMGB1 Protein, Mouse IgG2a Fc Tag (HM1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 2 - Glu 215 (Accession # P09429-1).
Species Reactivity：Human
Host：HEK293
Tag：N-mFc(mIgG2a)
Exp Region：Gly 2 - Glu 215
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P09429-1
Protein ID：NP_002119.1
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5
