Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family.
HCF2 is expressed predominantly in liver.
Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate.
In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III).
In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin.
Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 55.7 kDa.
The protein migrates as 66-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Serpin D1, His Tag (HC2-H5224) is expressed from human 293 cells (HEK293). It contains AA Gly 20 - Ser 499 (Accession # AAH35028).
