GM-CSF R alpha(Granulocyte-macrophage colony-stimulating factor receptor subunit alpha) is also known as CSF2RA, CD116, GMR-alpha.
Low affinity receptor for granulocyte-macrophage colony-stimulating factor.
Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells.
Hereditary pulmonary alveolar proteinosis (hPAP) is a rare disorder of pulmonary surfactant accumulation and hypoxemic respiratory failure caused by mutations in CSF2RA (encoding the granulocyte/macrophage colony-stimulating factor [GM-CSF] receptor α-chain [CD116]), which results in reduced GM-CSF-dependent pulmonary surfactant clearance by alveolar macrophages.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 60.9 kDa.
The protein migrates as 70-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human GM-CSF R alpha, Fc Tag (GRA-H5255) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Gly 320 (Accession # P15509-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Glu 23 - Gly 320
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P15509-1
Protein ID：NP_006131.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
