Gremlin is also known as Cysteine knot superfamily 1, BMP antagonist 1 (CKTSF1B1), DAN domain family member 2 (DAND2), Down-regulated in Mos-transformed cells protein (DRM), Increased in high glucose protein 2 (IHG-2), Cell proliferation-inducing gene 2 protein (PIG2) or Gremlin-1 (GREM1), which is highly expressed in small intestine, fetal brain and colon.
Gremlin / GREM-1 interacts with SLIT1 and SLIT2 in a glycosylation-dependent manner.
Gremlin may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop.
Gremlin down-regulates the BMP4 signaling in a dose-dependent manner and acts as inhibitor of monocyte chemotaxis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 44.2 kDa.
The protein migrates as 48-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Gremlin, Fc Tag (GR1-H5254) is expressed from human 293 cells (HEK293). It contains AA Lys 25 - Asp 184 (Accession # NP_037504).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Lys 25 - Asp 184
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：O60565
Protein ID：NP_037504
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：50 mM Tris, 150 mM NaCl, pH7.5 with 1 mM EDTA
