Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system.
Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.
Cerebroglycan has especially high affinity for laminin-1.
GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis.
Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models.
A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 60.0 kDa.
The protein migrates as 55-120 kDa under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Glypican 2, His Tag (GP2-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Gly 554 (Accession # Q8N158-1).
