Human NKG2C (NK cell Group 2 isoform C; Killer cell lectin-like receptor subfamily C, member 2) is a member of the C-type lectin-like superfamily of proteins.
NKG2C plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.
The CD94/NKG2C killer lectin-like receptor (KLR) specific for HLA-E is coupled to the KARAP/DAP12 adapter in a subset of NK cells, triggering their effector functions.
CD94/NKG2C may operate as an alternative activation pathway for a subset of CD8+ T lymphocytes, triggering their effector functions and proliferation upon specific ligand engagement.
特徴
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 17.8 kDa.
The protein migrates as 30-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human NKG2C, His Tag (NKC-H5248) is expressed from human 293 cells (HEK293). It contains AA Ile 94 - Leu 231 (Accession # P26717-1).
