Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system.
Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons.
Cerebroglycan has especially high affinity for laminin-1.
GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis.
Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models.
A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 84.6 kDa.
The protein migrates as 120k Da under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Glypican 2, Fc Tag (GP2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 553 (Accession # Q8N158-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Ser 24 - Ser 553
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q8N158-1
Protein ID：NP_689955.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
