May be involved in lipid homeostasis and ER stress pathways.
ILDR2 as a novel B7-like protein with robust T cell inhibitory activity, expressed in immune cells and in immune-privileged and inflamed tissues.
A fusion protein, consisting of ILDR2 extracellular domain with an Fc fragment, that binds to a putative counterpart on activated T cells showed a beneficial effect in the collagen-induced arthritis model and abrogated the production of proinflammatory cytokines and chemokines in autologous synovial-like cocultures of macrophages and cytokine-stimulated T cells.
Collectively, these findings point to ILDR2 as a novel negative regulator for T cells, with potential roles in the development of immune-related diseases, including autoimmunity and cancer.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 45.1 kDa.
The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to Glycosylation.
仕様
容量：100ug
Source：Human ILDR2, Fc Tag (IL2-H5259) is expressed from human 293 cells (HEK293). It contains AA Leu 21 - Glu 186 (Accession # Q71H61-1).
