Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily.
GHR contains one fibronectin type-III domain.
GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle.
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE.
GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 29.6 kDa.
The protein migrates as 40-60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：200ug
Source：MABSol Biotinylated Human GHR Protein, His Tag, primary amine labeling (GHR-H8222) is expressed from human HEK293 cells. It contains AA Ala 27 - Tyr 264 (Accession # P10912-1). It is the biotinylated form of Human Growth Hormone R (GHR) Protein (GHR-H5222).
