Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily.
GHR contains one fibronectin type-III domain.
GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle.
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE.
GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 54.3 kDa.
As a result of glycosylation, the protein migrates as 66-85 kDa under reducing (R) condition, and 135-160 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：50ug
Source：Human GHR, Fc Tag (GHR-H5257) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Tyr 264 (Accession # P10912).
