Growth hormone receptor (GHR) is also known as somatotropin receptor, growth hormone-binding protein (GHBR), which belongs to the type I cytokine receptor family or Type 1 subfamily.
GHR contains one fibronectin type-III domain.
GHR / GHBR is expressed in various tissues with high expression in liver and skeletal muscle.
The soluble form (GHBP) is produced by phorbol ester-promoted proteolytic cleavage at the cell surface (shedding) by ADAM17/TACE.
GHR is receptor for pituitary gland growth hormone involved in regulating postnatal body growth.
On ligand binding, couples to the JAK2/STAT5 pathway.
The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 54.7 kDa.
The protein migrates as 66-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Rhesus macaque GHR, Fc Tag (GHR-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 19 - Tyr 264 (Accession # P79194-1).
Species Reactivity：Rhesus macaque
Host：HEK293
Tag：C-Fc
Exp Region：Phe 19 - Tyr 264
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P79194-1
Protein ID：NP_001036132.1
Endotoxin：1.0 EU per μg
Purity：90%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
