G-protein coupled receptor for glucagon that plays a central role in the regulation of blood glucose levels and glucose homeostasis.
Regulates the rate of hepatic glucose production by promoting glycogen hydrolysis and gluconeogenesis.
Plays an important role in mediating the responses to fasting.
Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase.
Promotes activation of adenylate cyclase.
Besides, plays a role in signaling via a phosphatidylinositol-calcium second messenger system.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 14.9 kDa.
The protein migrates as 28-40 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human GCGR, His Tag (GCR-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ala 26 - Lys 136 (Accession # P47871-1).
