83-3845-13　Human G-CSF R / CD114 Protein, Fc Tag 1mg　GCR-H5250-1mg

特徴

• 背景
• Granulocyte Colony Stimulating Factor Receptor (G-CSFR) is also known as Cluster of Differentiation 114 (CD114), CSF3R and GCSF, is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF), a cytokine that plays a critical role in the regulation of the activation, proliferation, differentiation, and survival of the neutrophilic granulocyte lineage.
• G-CSFR belongs to a family of cytokine receptors known as the hematopoietin receptor family.
• This type I  membrane protein has a composite structure consisting of an immunoglobulin(Ig)-like domain, a cytokine receptor-homologous (CRH) domain and three fibronectin type I II (FNIII) domains in the extracellular region.
• G-CSFR is present mainly on precursor cells in the bone marrow, and, in response to stimulation by G-CSF, initiates cell proliferation and differentiation into mature neutrophilic granulocytes and macrophages.
• G-CSFR mediates the specific effect of GCSF through activating a variety of intracellular signaling cascades, including the Jak/Stat, PI3/Akt, Ras-Raf-MAP kinase, and Src family kinase pathways, and thus functions in defense against infection, inflammation and repair, and in the maintenance of steady state hematopoiesis.
• Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia.
• Mutations in the intracellular part of this receptor are also associated with certain types of leukemia.
• 特徴
• This protein carries a human IgG1 Fc tag at the C-terminus.
• The protein has a calculated MW of 92.7 kDa.
• The protein migrates as 100-120 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.