Frizzled-4 (FZD4) is also known as FzE4, CD344, which belongs to the G-protein coupled receptor Fz/Smo family.
Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
FZD4 contains one FZ (frizzled) domain.
FZD4 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
FZD4 interacts with MAGI3 and norrin (NDP).
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 42.9 kDa.
The protein migrates as 50-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human Frizzled-4, Fc Tag (FZ4-H5250) is expressed from human 293 cells (HEK293). It contains AA Phe 37 - Glu 180 (Accession # AAI14528).
