Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family.
Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
FZD2 contains one FZ (frizzled) domain.
FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 44.4 kDa.
The protein migrates as 50-62 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Frizzled-2, Fc Tag (FZ2-H5255) is expressed from human 293 cells (HEK293). It contains AA Gln 24 - Pro 190 (Accession # Q14332-1).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Gln 24 - Pro 190
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：Q14332-1
Protein ID：NP_001457.1
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
