Frizzled-10 (FZD10) is also known as FzE7 or CD350, which belongs to the G-protein coupled receptor Fz/Smo family.
Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes.
FZD10 contains one FZ (frizzled) domain.
FZD10 protein is a cell surface receptor, which is activated by Wnt proteins and involved in the regulation of cellular function.
FZD10 interacts with WNT7B and MYOC.
特徴
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 18.0 kDa.
The protein migrates as 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：1mg
Source：Human Frizzled-10, His Tag (FRD-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 21 - Gly 161 (Accession # Q9ULW2-1).
