Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs).
VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.
VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development.
It is likely that VEGF R3 may be important for lymph angiogenesis.
特徴
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 111.2 kDa.
As a result of glycosylation, the protein migrates as 140-160 kDa under reducing (R) condition, and 280-320 kDa under non-reducing (NR) condition (SDS-PAGE).
仕様
容量：1mg
Source：Human VEGF R3, Fc Tag (FL4-H5251) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Ile 776 (Accession # NP_002011.2).
Species Reactivity：Human
Host：HEK293
Tag：C-Fc
Exp Region：Tyr 25 - Ile 776
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P35916
Protein ID：NP_002011.2
Endotoxin：1.0 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
