Human epidermal growth factor (EGF) is also known as HOMG4 and URG,and is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to its receptor EGFR.
Epidermal growth factor can be found in human platelets, macrophages, urine, saliva, milk, and plasma.
EGF is the founding member of the EGF-family of proteins.
Members of this protein family have highly similar structural and functional characteristics.
All family members contain one or more repeats of the conserved amino acid sequence.
The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid, bile acids, pepsin, and trypsin and to physical, chemical and bacterial agents.
Because of the increased risk of cancer by EGF, inhibiting it decreases cancer risk.
特徴
This protein carries a mouse IgG2a Fc tag at the N-terminus.
The protein has a calculated MW of 33.1 kDa.
The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
仕様
容量：100ug
Source：Human EGF, Mouse IgG2a Fc Tag (EGF-H525b) is expressed from human 293 cells (HEK293). It contains AA Asn 971 - Arg 1023 (Accession # P01133-1).
Species Reactivity：Human
Host：HEK293
Tag：N-mFc(mIgG2a)
Exp Region：Asn 971 - Arg 1023
Format：Powder
Conjugate：Unconjugated
Swiss-Prot：P01133-1
Protein ID：NP_001954.2
Endotoxin：0.1 EU per μg
Purity：95%
Buffer：Tris with Glycine, Arginine and NaCl, pH7.5
